Correlation between hepatic immunological markers and virus genotype in patients with chronic hepatitis C / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 452-455, 2006.
Article
in Zh
| WPRIM
| ID: wpr-285101
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the hepatic expression of immunological markers relevant to a cytotoxic response in relation to viral genotype.</p><p><b>METHODS</b>The frozen liver biopsies were obtained from 28 HF genotyped patients and made the sections stained. The morphometry was used to analyze the major histocompatibility complex class I (MHC-I), CD8, beta(2)-microglobulin (beta(2) -mG), HFE and CD68 in the stained sections. Biopsy data of response to therapy with interferon were available in 18 cases.</p><p><b>RESULTS</b>CD8+ was usually clustered together and localized in portal tracts and sinusoids, and seen to interact with MHC I positive lining cells. MHC-I and beta(2) -mG were expressed mainly in endothelial and Kupffer cells. HFE was expressed in most round and dendritic CD68+ cells. Patients with virus genotype 3a had higher hepatic MHC-I and HFE expression, and a better sustained response to interferon (IFN) therapy than patients without.</p><p><b>CONCLUSION</b>The MHC-I expression in the liver of patient with chronic hepatitis C virus infection seems to relate to viral-genotype. The hepatic MHC-I and HFE expression are higher in patients with virus genotype 3a than that in patients with non-3a genotype.</p>
Full text:
1
Database:
WPRIM
Main subject:
Antiviral Agents
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Virology
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Enzyme-Linked Immunosorbent Assay
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Antigens, Differentiation, Myelomonocytic
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Histocompatibility Antigens Class I
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Antigens, CD
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Blotting, Western
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Interferons
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CD8 Antigens
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Hepacivirus
Limits:
Adult
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Female
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Humans
/
Male
Language:
Zh
Journal:
Chinese Journal of Medical Genetics
Year:
2006
Document type:
Article