An associated analysis of estrogen receptor 2 gene polymorphism linked with intrahepatic cholestasis of pregnancy / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 434-436, 2006.
Article
in Zh
| WPRIM
| ID: wpr-285107
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relation ship of estrogen receptor 2 gene (ESR2) polymorphism associated with intrahepatic cholestasis of pregnancy (ICP) in Chengdu of China.</p><p><b>METHODS</b>By polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method, the Rsa I polymorphism in exon 5 and the Alu I polymorphism in exon 8 of ESR2 were detected in 100 pregnant women with ICP (ICP group) and 100 normal pregnant women (control group) in Chengdu.</p><p><b>RESULTS</b>(1) The frequency of the allele A of Alu I polymorphism in exon 8 was significantly higher in ICP group than in control group (P=0.031, OR=1.975), so did the frequency of the Aa+AA genotypes (P=0.028, OR=2.144). (2) The genotype distributions (rr, Rr and RR) and allele frequencies (r and R) of Rsa I polymorphism in exon 5 were not significantly different between the two groups (P>0.05).</p><p><b>CONCLUSION</b>The Alu I polymorphism in exon 8 of ESR2 may be associated with the susceptibility of ICP in Chengdu. The Aa+AA genotype significantly elevated the risk suffering from the ICP. The Rsa I polymorphism in exon 5 of ESR2 is not associated with the risk getting the ICP in Chengdu.</p>
Full text:
1
Database:
WPRIM
Main subject:
Polymorphism, Genetic
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Pregnancy Complications
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Polymorphism, Restriction Fragment Length
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Cholestasis, Intrahepatic
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Genetic Predisposition to Disease
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Estrogen Receptor beta
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Gene Frequency
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Genetics
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Genotype
Limits:
Female
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Humans
/
Pregnancy
Language:
Zh
Journal:
Chinese Journal of Medical Genetics
Year:
2006
Document type:
Article