Alpha-glucosidase inhibitors from leaves of Forsythia suspense in Henan province / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 1156-1159, 2010.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-285382
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>The alpha-glucosidase inhibitory compounds were searched from Forsythia suspense.</p><p><b>METHOD</b>The active compounds were isolated by the method of bioassay-guided in vitro and column chromatographic techniques. The structures of compounds were identified by MS and NMR spectroscopy. The inhibitory kinetics of the isolated compounds were investigated.</p><p><b>RESULT</b>The ethyl acetate extract showed the strongest inhibitory activity, and five active compounds were isolated from this extract. The IC50 value of compound 1-5 were all lower than that of acarbose as positive control. Compound 1, the mixture of 1, 2 and 4 all showed noncompetitive type model on alpha-glucosidase.</p><p><b>CONCLUSION</b>Compound 1-3 as the inhibitors of alpha-glucosidase were reported for the first time. Compound 3 was isolated from the genus for the first time.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Plant Extracts
/
Kinetics
/
Chemistry
/
China
/
Plant Leaves
/
Forsythia
/
Enzyme Inhibitors
/
Alpha-Glucosidases
/
Glycoside Hydrolase Inhibitors
Country/Region as subject:
Asia
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2010
Document type:
Article