Percutaneous valve stent insertion to correct the pulmonary regurgitation: an animal feasibility study / 中华医学杂志(英文版)
Chinese Medical Journal
; (24): 3127-3131, 2010.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-285718
Responsible library:
WPRO
ABSTRACT
<p><b>BACKGROUND</b>Pulmonary regurgitation leads to progressive right ventricular dysfunction, susceptibility to arrhythmias, and sudden cardiac death. Percutaneous valve replacement has been developed in recent years, providing patients with an alternative option. Percutaneous pulmonary valve replacement has been recently introduced into clinical practice. The goal of this study was to evaluate the feasibility of percutaneous valve stent insertion to correct the pulmonary regurgitation in sheep using a cup-shaped valve stent.</p><p><b>METHODS</b>Pulmonary regurgitation was created by percutaneous cylindrical stent insertion in native pulmonary annulus of 8 sheep. One month after the initial procedure, the sheep with previous cylindrical stent implanted underwent the same implantation procedure of pulmonary valve stent. The valve stent consisted of a cup-shaped stent and pericardial valves. Hemodynamic assessments of the bioprosthetic pulmonary valve were obtained by echocardiography at immediately post-implant and at 2 months follow up.</p><p><b>RESULTS</b>Successful transcatheter cylindrical stent insertion was performed in 7 sheep but failed in 1 sheep because the cylindrical stent was released to right ventricle outflow tract. After one month the 7 sheep with pulmonary regurgitation underwent valve stent implantation successfully. Echocardiography confirmed the stents were in desired position during the follow-up. No evidence of pulmonary valve insufficiency occurred in any animals. Echocardiography showed all heart function markers were normal.</p><p><b>CONCLUSIONS</b>Percutaneous cylindrical stent insertion to induce significant pulmonary regurgitation in sheep was feasible, simple and reproducible. Percutaneous pulmonary valve stent implantation can reduce pulmonary regurgitation in a sheep model. Further development of animal model and clinical trials are warranted.</p>
Full text:
Available
Health context:
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Cardiovascular Disease
Database:
WPRIM (Western Pacific)
Main subject:
Pulmonary Valve Insufficiency
/
General Surgery
/
Heart Valve Prosthesis
/
Sheep
/
Feasibility Studies
/
Heart Valve Prosthesis Implantation
Limits:
Animals
Language:
English
Journal:
Chinese Medical Journal
Year:
2010
Document type:
Article