Intensive glycemic control and macrovascular events in type 2 diabetes mellitus: a meta-analysis of randomized controlled trials / 中华医学杂志(英文版)
Chinese Medical Journal
; (24): 2908-2913, 2010.
Article
in En
| WPRIM
| ID: wpr-285812
Responsible library:
WPRO
ABSTRACT
<p><b>BACKGROUND</b>There is no agreement as to whether intensive glucose control in type 2 diabetes can reduce the incidence of macrovascular events in these patients. We performed a meta-analysis comparing intensive glucose control or conventional glucose control in randomized controlled trials.</p><p><b>METHODS</b>Databases including MEDLINE, EMBASE, and Cochrane controlled trials register, the Cochrane Library, and Science Citation Index were searched to find relevant trials. Outcome measures were the incidence of major macrovascular events.</p><p><b>RESULTS</b>Six trials involving 28 065 patients were included. Analysis suggested that there was an obviously decreased incidence of major macrovascular events in patients having intensive glucose treatment vs. controls (RR 0.92; 95%CI 0.87, 0.98; P = 0.005). However, intensive glycemia control strategies in type 2 diabetes showed no significant impact on the incidence of death from any cause compared with conventional glycemia control strategies, intensive 14.7%, controls 12.0% (RR 0.95; 95%CI 0.80, 1.12; P = 0.55), as well as on the incidence of cardiovascular death, intensive 3.7%, controls 3.6% (RR 1.10, 95%CI 0.79, 1.53; P = 0.57).</p><p><b>CONCLUSIONS</b>Control of glycemia to normal (or near normal levels) in type 2 diabetes appears to be effective in reducing the incidence of major macrovascular events, but there were no significant differences of either the mortality from any cause or from cardiovascular death between the two glycemia-control strategies.</p>
Full text:
1
Database:
WPRIM
Main subject:
Blood
/
Blood Glucose
/
Glycated Hemoglobin
/
Randomized Controlled Trials as Topic
/
Mortality
/
Diabetes Mellitus, Type 2
/
Diabetic Angiopathies
/
Drug Therapy
Type of study:
Clinical_trials
/
Prognostic_studies
/
Systematic_reviews
Limits:
Humans
Language:
En
Journal:
Chinese Medical Journal
Year:
2010
Document type:
Article