Comparison of clinical characteristics of non-B non-C hepatocellular carcinoma and hepatitis virus-related hepatocellular carcinoma and prognosis in Uighur patients / 中华肿瘤杂志
Chinese Journal of Oncology
; (12): 540-544, 2015.
Article
in Zh
| WPRIM
| ID: wpr-286783
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>This study was aimed to understand the clinical characteristics and prognosis in Uighur patients with Non-B Non-C hepatocellular carcinoma (HCC) and virus-related HCC.</p><p><b>METHODS</b>We retrospectively analyzed the clinical data of 301 Uighur HCC patients, among them, there were 145 NBC-HCC cases and 156 virus-related HCC cases. The overall survival rates of the patients were analyzed by Kaplan-Meier method, and the factors that may influence the prognosis and survival of NBC-HCC patients were analyzed using univariate (Log rank test) and multivariate Cox proportional hazard model.</p><p><b>RESULTS</b>The differences of the gender, living region, history of diabetes, body mass index (BMI), history of cirrhosis, TNM stage, Child-Pugh scores, total bilirubin, and AFP level between the NBC-HCC group and viral-HCC group were statistically significant (P < 0.05 for all). The 1-, 2-, 3- and 5-year survival rates were 35.6%, 20.3%, 12.6%, and 4.5%, respectively, for all the 301 patients, and no significant difference between these two groups in terms of OS (P > 0.05). Multivariate analysis by Cox model showed that age, TNM staging, PVTT, Child-Pugh scores, TACE combined with radiotherapy or RFA were significant independent prognostic factors (all P < 0.05).</p><p><b>CONCLUSIONS</b>The clinical characteristics in Uighur patients with non-B non-C HCC and hepatitis virus-related HCC are not all the same and HCC in Xinjiang region has certain regional characteristics and features. Age, TNM stages, portal vein tumor thrombus, Child-Pugh scores, and TACE combined with radiotherapy or RFA are significant independent prognostic factors.</p>
Full text:
1
Database:
WPRIM
Main subject:
Portal Vein
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Prognosis
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Therapeutics
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Thrombosis
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Virology
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Proportional Hazards Models
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Sex Factors
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Multivariate Analysis
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Survival Rate
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Retrospective Studies
Type of study:
Observational_studies
/
Prognostic_studies
Limits:
Female
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Humans
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Male
Language:
Zh
Journal:
Chinese Journal of Oncology
Year:
2015
Document type:
Article