Protective effect of nitric oxide on gastric mucosa and its relationship to the acid secretion of gastric parietal cells under stress in rats / 中国应用生理学杂志
Chinese Journal of Applied Physiology
; (6): 301-304, 2005.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-287027
Responsible library:
WPRO
ABSTRACT
<p><b>AIM</b>To demonstrate the protective effect of nitric oxide (NO) on gastric mucosa and its relationship to the acid secretion of parietal cells under stress in rats.</p><p><b>METHODS</b>Water immersion-restraint stress (WRS) model in SD rats was performed. The gastric mucosal ulcer index (UI), NO contents in gastric mucosa and H+, K(+) -ATPase activity of parietal cells were measured. The effects of N(G)-nitro-L-arginine methyl ester(L-NAME) and L-arginine (L-Arg) on the H+, K(+)-ATPase activity of parietal cells and stress-induced gastric mucosal lesion were observed.</p><p><b>RESULTS</b>L-NAME pretreatment decreased NO contents in gastric mucosa, activated H+, K(+) -ATPase activity of parietal cells and aggravated gastric mucosal lesion, whereas L-Arg pretreatment increased NO contents, inhibited H+, K(+) -ATPase activity and significantly ameliorated stress-induced gastric mucosal lesion.</p><p><b>CONCLUSION</b>Endogenous nitric oxide plays an important role in protecting gastric mucosa from stress-induced lesion by inhibiting H+, K(+) -ATPase activity of parietal cells.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Parietal Cells, Gastric
/
Pathology
/
Arginine
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Stomach Ulcer
/
Stress, Physiological
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Rats, Sprague-Dawley
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H(/)-K(/)-Exchanging ATPase
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Oxidative Stress
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Nitric Oxide Synthase
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Bodily Secretions
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Applied Physiology
Year:
2005
Document type:
Article