Pharmacokinetic and tissue distribution study of scutellarin in rats / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 1688-1692, 2007.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-287864
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the pharmacokinetic and distribution character of scutellarin in plasma and tissues in rats, in order to provide some references for rational drug use in the clinic.</p><p><b>METHOD</b>The solution of scutellarin was administered to rats (80 mg x kg(-1)) by oral gavage. A high performance liquid chromatography method determinated the scutellarin concentration in rat plasma and tissue. The plasma samples were performed by solid phase extraction method. The other biological samples were extracted by ethyl acetate.</p><p><b>RESULT</b>The range of scutellarin in plasma and tissue in rats were 10-1280 ng x mL(-1) (R2 > 0.99), 40-1280 ng x g(-1) (R2 > 0.99), respectively. The lowest detection of scutellarin were 10 ng x mL(-1) and 40 ng x g(-1), the precision were less than 8%. The main pharmacokinetic parameters of scutellarin were as follows tmax, Cmax, AUC and MRT being (7.7 +/- 0.9) h, (288.0 +/- 75.2) microg x L(-1), (5.6 +/- 1.6) microg x mL(-1) x h(-1), (17.5 +/- 1.4) h(-1), respectively.</p><p><b>CONCLUSION</b>These methods applied the study of pharmacokinetics of scutellarin. After oral the scutellarin in rats, the concentration-time course doesn't obey any compartment model. The concentration-time curve is the double peaks.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Plants, Medicinal
/
Blood
/
Pharmacokinetics
/
Tissue Distribution
/
Chemistry
/
Chromatography, High Pressure Liquid
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Rats, Sprague-Dawley
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Area Under Curve
/
Apigenin
/
Glucuronates
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2007
Document type:
Article