Effects of kaixinsan on behavior and expression of p-CREB in hippocampus of chronic stress rats / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 1555-1558, 2007.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-287915
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the effects of kaixinsan on behavior and expression of p-CREB in hippocampus of the chronic stress rats.</p><p><b>METHOD</b>The male Wistar rats which gained the similar scores by Open-field test were selected, then the depression model rat was produced by separation and chronic unpredictable mild stress. Open-field test was performed to detect the behavior of rats and immunohistochemistry was used to observe the changes of p-CREB expression in hippocampus.</p><p><b>RESULT</b>On the 22nd day, the body weight and sacchar-intake of the depression model rats were all lower than those of the normal rats and the body weight and sacchar-intake of the rats treated by drugs were higher compared with model rats (P < 0.01). The depressive behavior in kaixinsan 4 g x kg(-1) group was significantly improved compared with the model group, the crossing scores and rearing scores were all increased (P < 0.01) and the expression of p-CREB in CA1, CA3 and DG in hippocampus was higher than that in the model group (P < 0.05 and P < 0.01).</p><p><b>CONCLUSION</b>Kaixinsan might improve depressive behavior by increasing expression of p-CREB in CA1, CA3 and DG in hippocampus of the chronic stress rats.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Plants, Medicinal
/
Stress, Psychological
/
Behavior, Animal
/
Drugs, Chinese Herbal
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Random Allocation
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Chemistry
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Rats, Wistar
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Cyclic AMP Response Element-Binding Protein
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Depression
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2007
Document type:
Article