Inadvertent Transmission of a Donor's Constitutional Chromosome Abnormality after Hematopoietic Stem Cell Transplantation
Soonchunhyang Medical Science
; : 137-141, 2015.
Article
in En
| WPRIM
| ID: wpr-28804
Responsible library:
WPRO
ABSTRACT
A pre-transplant screening work-up of donors for allogeneic hematopoietic stem cell transplantation (HSCT) is essential. Inadvertent transmission of malignancy from donors with subclinical diseases to recipients has been reported recently in several cases. A 49-year-old male was diagnosed with acute myeloid leukemia. He underwent a course of induction chemotherapy and achieved cytogenetic complete remission (CR). He was treated with an additional cycle of consolidation chemotherapy followed by full matched sibling allogeneic HSCT due to an additional deletion in 9q known as an adverse prognostic factor. Post transplantation bone marrow biopsy revealed molecular CR, but conventional cytogenetics identified the presence of 46,XY,t(1:2)(p32:q35). A cytogenetic analysis of the donor graft specimen revealed t(1:2). We confirmed the donor origin of t(1:2). We report the first case of a person with constitutional t(1;2) serving as a stem cell donor.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Stem Cells
/
Tissue Donors
/
Biopsy
/
Bone Marrow
/
Hematopoietic Stem Cells
/
Leukemia, Myeloid, Acute
/
Leukemia
/
Mass Screening
/
Chromosome Aberrations
/
Hematopoietic Stem Cell Transplantation
Type of study:
Prognostic_studies
/
Screening_studies
Limits:
Humans
/
Male
Language:
En
Journal:
Soonchunhyang Medical Science
Year:
2015
Document type:
Article