Observation on effect of badu shengji san and its decomposed recipes on morphological changes of injured skin tissues in rats / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the effect of Badu Shengji San (BDSJS) and its decomposed recipes on morphological changes of injured skin in rats.</p><p><b>METHOD</b>SD rats with injured skin were treated with BDSJS and its different decomposed recipes for consecutively 14 days. Morphological changes in the injured skin were observed by H&E staining.</p><p><b>RESULT</b>Mercury and lead-containing ingredients significantly decreased epidermal thickness and caused vascular hemorrhage, hyperemia and inflammatory cell infiltration in reticular layer of dermis. The compatible herbs alleviated epidermal thickness and reduced dermal lesions.</p><p><b>CONCLUSION</b>BDSJS' mercury and lead-containing ingredients can accelerate the healing of skin wound and its compatible herbs can relieve the dermis injury induced by mercury and lead.</p>