Clinical features of childhood hemophagocytic syndrome and its association with human parvovirus B19 infection / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 26-30, 2015.
Article
in Zh
| WPRIM
| ID: wpr-289476
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association of childhood hemophagocytic syndrome (HPS) with human parvovirus B19 (HPVB19) infection, and to analyze the clinical features of this disease.</p><p><b>METHODS</b>ELISA and quantitative real-time PCR were used to detect HPVB19-IgM, HPVB19-IgG and HPVB19-DNA in 65 children with HPS (HPS group) and 65 healthy children (control group). The HPS group was divided into HPVB19-infected (n=14) and non-infected (n=51) groups according to the detection results of HPVB19-DNA. The clinical data of two groups were compared.</p><p><b>RESULTS</b>The positive rate of HPVB19-IgM in the HPS group (26%, 17/65) was significantly higher than that in the control group (9%, 6/65) (P=0.011), and there was no significant difference in the positive rate of HPVB19-IgG between the HPS (38%, 25/65) and control groups (29%, 19/65) (P=0.266). The infection rate of HPVB19 in the HPS group (22%, 14/65) was significantly higher than that in the control group (3%, 2/65) (P=0.001). Compared with the non-infected group, the HPVB19-infected group had significantly lower platelet count and hemoglobin level on admission, significantly more severe liver function damage, a significantly earlier onset time, and a significantly longer course of disease (P<0.05).</p><p><b>CONCLUSIONS</b>The pathogenesis of HPS may be associated with HPVBl9 infection. HPVBl9-infected children with HPS have more acute onset, more severe clinical manifestations, and a longer disease duration.</p>
Full text:
1
Database:
WPRIM
Main subject:
DNA, Viral
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Parvovirus B19, Human
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Parvoviridae Infections
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Lymphohistiocytosis, Hemophagocytic
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Antibodies, Viral
Limits:
Adolescent
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Child
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Child, preschool
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Female
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Humans
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Infant
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Male
Language:
Zh
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2015
Document type:
Article