An experimental study on c-myc gene mRNA expression of endothelial cell induced by bFGF / 中华整形外科杂志
Chinese Journal of Plastic Surgery
; (6): 299-301, 2002.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-292073
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the molecular biological mechanism of endothelial cell proliferation induced by bFGF.</p><p><b>METHODS</b>Cultured rat myocardial microvascular endothelial cells were stimulated with bFGF of various concentrations. By northern blot analysis, the levels of c-myc mRNA expression were detected.</p><p><b>RESULTS</b>The expression of c-myc mRNA in the bFGF-treated groups increased (P < 0.05) with a dose- and stimulating time-dependent manner. The c-myc mRNA expression reached to a peak level at 2 hours.</p><p><b>CONCLUSIONS</b>C-myc expression may be an important component in controlling the transit of cells through the cell cycle.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Time Factors
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RNA, Messenger
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Endothelium, Vascular
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Cell Division
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Cells, Cultured
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Gene Expression Regulation
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Fibroblast Growth Factor 2
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Genes, myc
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Rats, Sprague-Dawley
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Plastic Surgery
Year:
2002
Document type:
Article