Meta-analysis of laparoscopy-assisted distal gastrectomy and conventional open distal gastrectomy for early gastric cancer / 癌症

ABSTRACT

<p><b>BACKGROUND AND OBJECTIVE</b>With the application of laparoscopy, laparoscopic gastrectomy for the treatment of patients with early gastric cancer has been performed, but the safety and effectiveness of this method need to be explored. This study evaluated the safety and effectiveness of laparoscopy-assisted and conventional open distal gastrectomy for patients with early gastric cancer.</p><p><b>METHODS</b>A search of MEDLINE, EMBASE, the Chinese Biomedical Database (CBM), and Cochrane Central Register of Controlled Trials (CENTRAL) identified all the randomized clinical trials that compared laparoscopy-assisted gastrectomy with open distal gastrectomy for patients with early gastric cancer published in the last 10 years. Quality assessment was done on each trial and relevant data were extracted from qualified trials. Meta-analysis was performed using RevMan 4.2.2 software (Cochrane).</p><p><b>RESULTS</b>Six randomized controlled trials (RCTs) involving 218 patients were included. Comparing laparoscopic resection with open resection, results showed less estimated blood loss (WMD (weighted mean difference) -121.86; 95% CI (confidence interval) -145.61, -98.11; P < 0.001), earlier postoperative first flatus (WMD -0.95; 95% CI -1.09, -0.81; P < 0.001), and shorter durations of hospital stays (WMD -2.27; 95%CI -3.47, -1.06; P = 0.0002), but longer surgery times (WMD 58.71; 95% CI 52.69, 64.74; P < 0.001) and fewer lymph nodes dissected (WMD -3.64; 95% CI -5.80,-1.47; P = 0.001). There was no significant difference between the two groups in postoperative complications (OR (odds ratio) 0.57; 95% CI 0.31,1.03; P = 0.06).</p><p><b>CONCLUSIONS</b>The short-term outcome of laparoscopy-assisted distal gastrectomy for patients with early gastric cancer is superior to the open procedure, but its long-term outcome should be proven by further outcomes of RCTs.</p>