Analysis of prognostic factors in 300 colorectal cancer patients with liver metastases / 中华肿瘤杂志

ABSTRACT

<p><b>OBJECTIVE</b>To analyse the clinical characteristics and potential prognostic factors of colorectal cancer patients with liver metastases.</p><p><b>METHODS</b>The clinical and pathological data of 300 colorectal cancer patients with liver metastases were retrospectively reviewed and analyzed.</p><p><b>RESULTS</b>The median survival time of these patients was 19.0 months. The 1-, 2- and 5-year survival rates after liver metastases were 79.0%, 29.0% and 3.0%, respectively. Univariate analysis revealed that performance status (KPS), histological grading, primary tumor, N status, lymphatic and vascular invasion, stage at diagnosis, the number, size and distribution of liver metastases and other accompanied metastases were prognostic factors. Multivariate analysis showed that KPS, lymphatic and vascular invasion, the number and size of liver metastases were independent prognostic factors of colorectal cancer with liver metastases.</p><p><b>CONCLUSION</b>Performance status, lymphatic and vascular invasion, the number and size of liver metastases are independent prognostic factors of colorectal cancer with liver metastases.</p>