Study on adscription of drug constituents in Beagle dog plasma after intragastric administration with Jiangzhining extract / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 912-914, 2008.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-295441
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the drug constituents in Beagle dog plasma after intragastric administration with Jiangzhining extract, which is a Chinese medicine prescription and it consisting of processed Radix Polygoni Multiflori, Fructus Crataegi, Semen Cassiae and Folium Nelumbinis.</p><p><b>METHOD</b>The drug constituents and their origin in Beagle dogs plasma were assigned by comparison of high-performance liquid chromatographic profiles, retention time and ultraviolet spectra of the drug-free plasma, plasma contained drug, Jiangzhining extract and the ingredients of crude drug.</p><p><b>RESULT</b>Twenty-four components were detected after intragastric administration of Jiangzhining extract, among which eight compounds were the original components existed in Jiangzhining extract and sixteen compounds were likely to metabolites of the some chemical constituents in ingredients of crude drug.</p><p><b>CONCLUSION</b>Studies on the drug constituents and the metabolites in plasma after intragastric administration of Jiangzhining extract are useful to elucidate the effective substances of Jiangzhining prescription.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Stomach
/
Drugs, Chinese Herbal
/
Chemistry
/
Chromatography, High Pressure Liquid
/
Serum
/
Metabolism
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2008
Document type:
Article