Application of mesenchymal stem cells as a vehicle to deliver replication-competent adenovirus for treating malignant glioma / 癌症
Chinese Journal of Cancer
; (12): 233-240, 2012.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-295890
Responsible library:
WPRO
ABSTRACT
Although gene therapy was regarded as a promising approach for glioma treatment, its therapeutic efficacy was often disappointing because of the lack of efficient drug delivery systems. Mesenchymal stem cells(MSCs) have been reported to have a tropism for brain tumors and thus could be used as delivery vehicles for glioma therapy. Therefore, in this study, we attempted to treat glioma by using MSCs as a vehicle for delivering replication-competent adenovirus. We firstly compared the infectivity of type 3, type 5, and type 35 fiber-modified adenoviruses in MSCs. We also determined suitable adenovirus titer in vitro and then used this titer to analyze the ability of MSCs to deliver replication-competent adenovirus into glioma in vivo. Our results indicated that type 35 fiber-modified adenovirus showed higher infectivity than did naked type 3 or type 5 fiber-modified adenovirus. MSCs carrying replication-competent adenovirus significantly inhibited tumor growth in vivo compared with other control groups. In conclusion, MSCs are an effective vehicle that can successfully transport replication-competent adenovirus into glioma, making it a potential therapeutic strategy for treating malignant glioma.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Therapeutics
/
Virus Replication
/
Brain Neoplasms
/
Random Allocation
/
Adenoviridae
/
Xenograft Model Antitumor Assays
/
Cell Line, Tumor
/
Mesenchymal Stem Cell Transplantation
/
Oncolytic Virotherapy
Type of study:
Controlled clinical trial
Limits:
Animals
/
Humans
Language:
English
Journal:
Chinese Journal of Cancer
Year:
2012
Document type:
Article