Advancement and prospects of tumor gene therapy / 癌症
Chinese Journal of Cancer
; (12): 182-188, 2011.
Article
in En
| WPRIM
| ID: wpr-296298
Responsible library:
WPRO
ABSTRACT
Gene therapy is one of the most attractive fields in tumor therapy. In past decades, significant progress has been achieved. Various approaches, such as viral and non-viral vectors and physical methods, have been developed to make gene delivery safer and more efficient. Several therapeutic strategies have evolved, including gene-based (tumor suppressor genes, suicide genes, antiangiogenic genes, cytokine and oxidative stress-based genes) and RNA-based (antisense oligonucleotides and RNA interference) approaches. In addition, immune response-based strategies (dendritic cell- and T cell-based therapy) are also under investigation in tumor gene therapy. This review highlights the progress and recent developments in gene delivery systems, therapeutic strategies, and possible clinical directions for gene therapy.
Full text:
1
Database:
WPRIM
Main subject:
Therapeutics
/
Dendritic Cells
/
Genetic Therapy
/
Genes, Tumor Suppressor
/
Gene Transfer Techniques
/
RNA Interference
/
Genes, Transgenic, Suicide
/
Allergy and Immunology
/
Genetic Vectors
/
Genetics
Limits:
Humans
Language:
En
Journal:
Chinese Journal of Cancer
Year:
2011
Document type:
Article