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Correlation analysis of efficacy of yiqi chutan recipe in treating NSCLC and P4HB expression / 中国中西医结合杂志
Article in Chinese | WPRIM (Western Pacific) | ID: wpr-297457
Responsible library: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the predicting effect of proly 4-hydroxylase beta polypeptide (P4HB) in treating non-small cell lung cancer (NSCLC) patients by Yiqi Chutan Recipe (YCR).</p><p><b>METHODS</b>Totally 46 stage III and IV NSCLC patients were treated by YCR for 4 therapeutic courses. Effect was assessed by RECIST of solid tumor. P4HB expression was detected in the lung cancer tissue by immunohistochemical assay. Factors affecting disease control rates (DCR) of YCR were analyzed by Logistic regression analysis. The correlation between P4HB expression and the effect of YCR was analyzed.</p><p><b>RESULTS</b>The DCR of advanced NSCLC treated by YCR was 36.96% (17/46 cases). P4HB was high expressed in advanced lung cancer tissue (6/15 cases). Gender, initial treatment, and retreatment are independent factors for affecting DCR of treating lung cancer by YCR.</p><p><b>CONCLUSION</b>P4HB might be taken as a factor for predicting the effect of YCR in treating NSCLC.</p>
Subject(s)
Full text: Available Database: WPRIM (Western Pacific) Main subject: Drugs, Chinese Herbal / Carcinoma, Non-Small-Cell Lung / Procollagen-Proline Dioxygenase / Protein Disulfide-Isomerases / Therapeutic Uses / Drug Therapy / Lung / Lung Neoplasms / Metabolism Type of study: Prognostic study Limits: Humans / Male Language: Chinese Journal: Chinese Journal of Integrated Traditional and Western Medicine Year: 2015 Document type: Article
Full text: Available Database: WPRIM (Western Pacific) Main subject: Drugs, Chinese Herbal / Carcinoma, Non-Small-Cell Lung / Procollagen-Proline Dioxygenase / Protein Disulfide-Isomerases / Therapeutic Uses / Drug Therapy / Lung / Lung Neoplasms / Metabolism Type of study: Prognostic study Limits: Humans / Male Language: Chinese Journal: Chinese Journal of Integrated Traditional and Western Medicine Year: 2015 Document type: Article
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