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Progress in the study of carbonic anhydrase inhibitors as potential anticancer drugs / 药学学报
Acta Pharmaceutica Sinica ; (12): 1637-1643, 2013.
Article in Chinese | WPRIM (Western Pacific) | ID: wpr-298032
Responsible library: WPRO
ABSTRACT
Carbonic anhydrase IX (CA IX) is a tumor associated protein which is able to be a potent anticancer target, since it is highly expressed in a multitude of carcinomas, while it is present in a limited number of normal tissues. This review focuses on its role in tumor physiology, the most recent three dimensional structure features of this enzyme which has recently been elucidated. In addition, we present recent advances in the development of small inhibitors able to target CA IX for therapeutic applications.
Subject(s)
Full text: Available Database: WPRIM (Western Pacific) Main subject: Carbonic Anhydrase Inhibitors / Chemistry / Carbonic Anhydrases / Therapeutic Uses / Drug Therapy / Carbonic Anhydrase IX / Metabolism / Antigens, Neoplasm / Neoplasms / Antineoplastic Agents Limits: Humans Language: Chinese Journal: Acta Pharmaceutica Sinica Year: 2013 Document type: Article
Full text: Available Database: WPRIM (Western Pacific) Main subject: Carbonic Anhydrase Inhibitors / Chemistry / Carbonic Anhydrases / Therapeutic Uses / Drug Therapy / Carbonic Anhydrase IX / Metabolism / Antigens, Neoplasm / Neoplasms / Antineoplastic Agents Limits: Humans Language: Chinese Journal: Acta Pharmaceutica Sinica Year: 2013 Document type: Article
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