Metabolism and excretion of total flavonoids of Semen Ziziphi Spinosae in rat urine and feces / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the metabolism and excretion of total flavonoids of Semen Ziziphi Spinosae in rat urine and feces.</p><p><b>METHOD</b>The urine and feces of rats were collected at different times after orally administration of total flavonoids from Semen Ziziphi Spinosae, disposed by HP-20 macroporous resin, and then detected by both HPLC and LC-MSn methods.</p><p><b>RESULT</b>Two main proto-drugs, spinosin and 6'"-feruloylspinosin, along with a metabolite, swertish (M1), are detected in both urine and feces of rat.</p><p><b>CONCLUSION</b>Flavonoids of Semen Ziziphi Spinosae are excreted in urine and feces mainly in form of proto-drug, while little in form of metabolites, such as swertish.</p>