Lung cancer diagnosis based on urinary modified nucleoside metabolic profiling / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 738-741, 2007.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-298698
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the feasibility of modified urinary nucleosides metabolic profiling on lung cancer diagnoses.</p><p><b>METHODS</b>The modified urinary nucleosides metabolic profiling from 42 normal adults and 80 patients with lung cancer were determined by a coupled-column high performance liquid chromatography system. Partial least squares-discriminant analysis (PLS-DA) models were used to class differentiation between the lung cancer patients and controls and to discover potential biomarkers.</p><p><b>RESULT</b>The PLS-DA model results showed that there was a clear differentiation between normal adults and lung cancers patients, with the value of prediction (Q2) equals to 0.744.</p><p><b>CONCLUSION</b>Modified urinary nucleosides metabolic profiling method is useful for lung cancer diagnoses.</p>
Full text:
Available
Health context:
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Other Malignant Neoplasms
/
Other Respiratory Diseases
/
Trachea, Bronchus, Lung Cancers
Database:
WPRIM (Western Pacific)
Main subject:
Urine
/
Biomarkers
/
Least-Squares Analysis
/
Diagnosis
/
Metabolome
/
Lung Neoplasms
/
Models, Biological
/
Nucleosides
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Adult
/
Humans
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2007
Document type:
Article