Association between positive autoantibodies against AT1-receptor and cardiac remodeling in patients with hypertension / 中华心血管病杂志

ABSTRACT

<p><b>OBJECTIVE</b>To observe the association between positive autoantibodies against AT(1)-receptor and cardiac remodeling in primary hypertensive patients.</p><p><b>METHODS</b>Echocardiography was performed and serum autoantibodies against AT(1)-receptor were detected by enzyme linked immunosorbent assay (ELISA) in 592 patients with primary hypertension. The differences on blood pressure level, course of hypertension, vasoactive substance and echocardiography parameters between the positive group and negative group were compared. Factors related to left ventricular enlargement were analyzed by multiple logistic regressions.</p><p><b>RESULTS</b>The positive percentage of autoantibodies against AT(1)-receptor was 38.0% (225/592). End-diastolic right atrial and left ventricular diameters in positive group were significantly larger than that in negative group (P = 0.049 and P = 0.044, respectively). Regression analysis demonstrated that positive autoantibodies against AT(1)-receptor, male gender, diastolic blood pressure and course of hypertension were related to left ventricular enlargement (all P < 0.05).</p><p><b>CONCLUSION</b>The autoantibodies against AT(1)-receptor is associated with left ventricular and right atrial enlargement in hypertensive patients.</p>