Single-dose ceftriaxone versus multiple-dose cefuroxime for prophylaxis of surgical site infection / 中华外科杂志
Chinese Journal of Surgery
; (12): 372-374, 2003.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-300028
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To compare the effects and pharmacoeconomics of single-dose of ceftriaxone versus 3-day cefuroxime prophylaxis in patients undergoing gastric or colorectal resection.</p><p><b>METHODS</b>Three hundred and five consecutive patients with gastric or colorectal cancer from 5 medical centers were randomly divided into ceftriaxone group (n = 153, receiving intravenously 1 g ceftriaxone 0.5 - 1 h prior to operation only) and cefuroxime group (n = 152, receiving 0.75 g cefuroxime preoperatively and the same dose q8h for 3 d). The patients' intra- and postoperative status, adverse responses and infectious complications were observed and documented, and pharmacoeconomic parameters were analyzed.</p><p><b>RESULTS</b>The disease distribution, operative procedures and patients' conditions in the 2 groups were comparable. No adverse responses to the test antibiotics were observed. Postoperative infectious complications occurred in 7 cases in the ceftriaxone group (4.58%) and 14 cases in the cefuroxime group (9.21%), respectively (P = 0.992), among which, 12 cases were surgical site infections (incisional, intra-abdominal) 2 cases in the ceftriaxone group (1.31%), and 10 cases in the cefuroxime group (6.58%), (chi(2) = 5.607, P = 0.018). The direct cost related to prevention and treatment of surgical site infections was 283.5 RMB in the ceftriaxone group and 811.1 RMB in the cefuroxime group (Z = 14.51, P = 0.000).</p><p><b>CONCLUSION</b>Both ceftriaxone and cefuroxime are safe and effective for prevention of surgical site infections. Single-dose ceftriaxone prophylaxis is sufficient for gastric and colorectal operations, with a better cost-effectiveness ratio.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Surgical Wound Infection
/
Ceftriaxone
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Cefuroxime
/
Prospective Studies
/
Treatment Outcome
/
Antibiotic Prophylaxis
/
Therapeutic Uses
/
Economics
/
Anti-Bacterial Agents
Type of study:
Health economic evaluation
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Observational study
Aspects:
Social determinants of health
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Surgery
Year:
2003
Document type:
Article