The natural history of occult choroidal neovascularisation associated with age-related macular degeneration. A systematic review
Annals of the Academy of Medicine, Singapore
; : 145-150, 2006.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-300134
Responsible library:
WPRO
ABSTRACT
<p><b>INTRODUCTION</b>The purpose of this review is to combine the results of existing literature on the natural history of occult choroidal neovascularisation (CNV) associated with age-related macular degeneration (AMD).</p><p><b>MATERIALS AND METHODS</b>Published reports evaluating eyes with occult CNV in AMD patients were selected for meta-analysis based on a computerised MEDLINE search. Pooled estimates of the proportions of eyes with a vision loss greater than 2 to 3 (moderate vision loss) or 6 lines (severe vision loss) at 1 year and 2 to 3 years, respectively, or developing a classic component on fluorescein angiography at 1 year were measured.</p><p><b>RESULTS</b>There is no significant heterogeneity among published rates of visual loss and development of classic CNV. The overall pooled estimates (95% confidence limits) of the proportions of eyes with at least moderate or severe vision loss, respectively, were 59% (53% to 64.5%) and 34% (25% to 43%) at 1 year and 70% (64% to 76%) and 47% (40% to 54%) at 2 to 3 years; the overall pooled estimate of the percentage of eyes developing classic CNV at 1 year was 46% (39% to 54%).</p><p><b>CONCLUSION</b>A substantial number of patients with occult CNV from AMD will develop at least moderate visual loss at 1 year and severe visual loss within 3 years. However, visual acuity may remain stable in up to 30% of patients. These results may help us to understand the exact role of new therapies and in planning future trials.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Vision, Low
/
Choroidal Neovascularization
/
Macular Degeneration
Type of study:
Systematic review
Limits:
Humans
Language:
English
Journal:
Annals of the Academy of Medicine, Singapore
Year:
2006
Document type:
Article