Unitary-core osmotic pump tablet for controlled release of water-insoluble drug / 药学学报
Acta Pharmaceutica Sinica
; (12): 966-967, 2003.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-301163
Responsible library:
WPRO
ABSTRACT
<p><b>AIM</b>To study unitary-core osmotic pump tablet for delivering water-insoluble drug for 24 hours.</p><p><b>METHODS</b>Unitary-core osmotic pump tablet was prepared using nifedipine as the model drug. The effects of various core formulation variables on drug release were studied.</p><p><b>RESULTS</b>Polyethylene oxide and potassium chloride have comparable positive effects on drug release, whereas, nifedipine has markedly negative effect on drug release.</p><p><b>CONCLUSION</b>Unitary-core osmotic pump tablet is very easy in preparation and it can deliver water-insoluble drug in substantially constant rate for 24 hours.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Osmosis
/
Pharmacology
/
Polyethylene Glycols
/
Potassium Chloride
/
Solubility
/
Tablets
/
Calcium Channel Blockers
/
Nifedipine
/
Chemistry
/
Technology, Pharmaceutical
Type of study:
Prognostic study
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2003
Document type:
Article