Prognostic factors predicting postoperative survival period in the treatment of primary retroperitoneal leiomyosarcoma / 中华外科杂志

ABSTRACT

<p><b>OBJECTIVE</b>To evaluate prognostic factors predicting postoperative period for patients with primary retroperitoneal leiomyosarcoma.</p><p><b>METHODS</b>The clinical data and prognosis of 35 patients with primary retroperitoneal leiomyosarcoma between August 2002 and June 2011 were retrospectively reviewed and analyzed.</p><p><b>RESULTS</b>The resectability rate of primary tumors was 91.4% (32/35) , and 71.4% (25/35) of the patients underwent complete resection. The 21 patients (84.0%) who got a complete resection of the primary tumor got tumor recurrence and died of tumor recurrence eventually. The overall 1-, 3-, 5-year survival rate were 82.9%, 54.3% and 31.4% and the median survival was 36 months. In the analysis of factors influencing postoperative survival, factors associated with postoperative survive were modus operandi of the tumor resection (χ(2) = 16.871, P = 0.000), tumor size (χ(2) = 5.548, P = 0.019) and tumor grade (χ(2) = 8.080, P = 0.014); the difference between age (χ(2) = 0.073, P = 0.787), gender (χ(2) = 2.181, P = 0.140) and adjuvant therapy (χ(2) = 1.344, P = 0.511) got no statistical significance.</p><p><b>CONCLUSIONS</b>The efficiency of adjuvant therapy for primary retroperitoneal leiomyosarcoma is not clear, complete resection remains the mainstream for primary leiomyosarcoma. Incomplete resection, large tumor (tumor diameter ≥ 10 cm) and high grade tumor predict shorter postoperative survival period.</p>