Clinical analysis of liver transplantation for autoimmune hepatitis / 中华肝脏病杂志
Chinese Journal of Hepatology
; (12): 860-864, 2015.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-303217
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To describe the outcomes and recurrence of autoimmune hepatitis (AIH) after liver transplantation.</p><p><b>METHODS</b>Clinical data of 16 patients with AIH who underwent liver transplantation were analyzed retrospectively. The postoperative cumulative survival rate of the patients was calculated. The postoperative rejections and AIH recurrence were analyzed. The Kaplan-Meier method was used for statistical analysis of survival.</p><p><b>RESULTS</b>All patients were female, with an average age of 52.6 years (range 41-66 years), and an average MELD score of 21.4. According serological analysis, 15 patients were AIH type 1 and 1 patient was AIH type 2. Three patients died, including 2 of pulmonary infection and 1 of graft dysfunction.The 1-, 2-and 5-year cumulative survival rates were 93.8%, 87.1% and 79.1%, respectively. Five cases (31.3%) of recurrent AIH were diagnosed based on histological evidence. Acute rejection occurred in 6 (37.5%) patients, and de novo HBV infection occurred in 1 (6.3%) patient.</p><p><b>CONCLUSION</b>Liver transplantation is an effective treatment for end-stage AIH. Recurrence and rejection were commonly associated with AIH, but did not negatively impact patient survival.</p>
Full text:
Available
Health context:
SDG3 - Health and Well-Being
Health problem:
Target 3.3: End transmission of communicable diseases
Database:
WPRIM (Western Pacific)
Main subject:
Postoperative Period
/
Recurrence
/
General Surgery
/
Survival Rate
/
Retrospective Studies
/
Liver Transplantation
/
Treatment Outcome
/
Hepatitis, Autoimmune
Type of study:
Observational study
Limits:
Adult
/
Aged
/
Female
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Hepatology
Year:
2015
Document type:
Article