Great efficacy of sulfachloropyrazine-sodium against acute murine toxoplasmosis
Asian Pacific Journal of Tropical Biomedicine
; (12): 70-75, 2012.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-303622
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To identify more effective and less toxic drugs to treat animal toxoplasmosis.</p><p><b>METHODS</b>Efficacy of seven kinds of sulfonamides against Toxoplasma gondii (T. gondii) in an acute murine model was evaluated. The mice used throughout the study were randomly assigned to many groups (10 mice each), which either remained uninfected or were infected intraperitoneally with tachyzoites of T. gondii (strains RH and CN). All groups were then treated with different sulfonamides and the optimal treatment protocol was determined candidates. Sulfadiazine-sodium (SD) was used for comparison.</p><p><b>RESULTS</b>The optimal therapy involved gavaging mice twice per day with 250 mg/kg bw of sulfachloropyrazine-sodium (SPZ) for five days. Using this protocol, the average survival time and the time-point of 50% fatalities were prolonged significantly compared with SD treatment. Treatment with SPZ protected 40% of mice from death, and the heart and kidney tissue of these animals was parasite-free, as determined by nested-PCR. SPZ showed excellent therapeutic effects in the treatment of T. gondii in an acute murine model and is therefore a promising drug candidate for the treatment and prevention of T. gondii in animals.</p><p><b>CONCLUSIONS</b>It can be concluded that the effective drug sulfachloropyrazine may be the new therapeutic options against animal toxoplasmosis.</p>
Full text:
Available
Health context:
SDG3 - Health and Well-Being
/
Neglected Diseases
Health problem:
Target 3.3: End transmission of communicable diseases
/
Neglected Diseases
/
Zoonoses
Database:
WPRIM (Western Pacific)
Main subject:
Parasitology
/
Sulfanilamides
/
Toxoplasma
/
Survival Analysis
/
Toxoplasmosis
/
Polymerase Chain Reaction
/
Administration, Oral
/
DNA, Protozoan
/
Treatment Outcome
/
Disease Models, Animal
Type of study:
Practice guideline
Limits:
Animals
Language:
English
Journal:
Asian Pacific Journal of Tropical Biomedicine
Year:
2012
Document type:
Article