The association study on infection of Mycobacterium leprae and RIPK2 / 나학회지
Korean Leprosy Bulletin
; : 23-29, 2003.
Article
in Korean
| WPRIM (Western Pacific)
| ID: wpr-30420
Responsible library:
WPRO
ABSTRACT
Receptor-interacting serine/threonine kinase 2(RIPK2) is an adaptor molecule involved in the signal pathway of TLRs. However, there is no report on association between RIPK2 expression and infectious disease including mycobacterial disease in which TLRs play main role on interaction of infection. We evaluated relationship between Mycobacterium leprae and RIPK 2 by real-time RT-PCR. This study revealed that RIPK2 expression was down-regulated in the footpads and skin but was up-regulated in the liver, lymph node, and spleen of Mycobacterium leprae-infected nu/nu mice compared with those of non-infected nu/nu mice. It was observed that the IL-12p40, IFN-gamma, and IL-18 involved in the susceptibility of Mycobacterium leprae were down-regulated in the skin and footpad but up-regulated in the liver. These results suggest that regulation of RIPK2 expression is tissue-specific and is associated with M. leprae infection.
Full text:
Available
Health context:
Neglected Diseases
Health problem:
Leprosy
Database:
WPRIM (Western Pacific)
Main subject:
Phosphotransferases
/
Skin
/
Spleen
/
Signal Transduction
/
Communicable Diseases
/
Interleukin-12
/
Interleukin-18
/
Interleukin-12 Subunit p40
/
Liver
/
Lymph Nodes
Limits:
Animals
Language:
Korean
Journal:
Korean Leprosy Bulletin
Year:
2003
Document type:
Article