Curative effects of the protocol of CDV combined with CiE as pre-operative chemotherapy in high-risk childhood neuroblastoma / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 885-887, 2009.
Article
in Zh
| WPRIM
| ID: wpr-305092
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the effects and the toxicity of the protocol of CDV combined with CiE as pre-operative chemotherapy in childhood stage IV neuroblastoma.</p><p><b>METHODS</b>The clinical data of 27 children aged from 1.2 to 8 years with neuroblastoma in stage IV was retrospectively studied. The primary sites of the diseases were abdomen (n = 21), posterior mediastinum (n = 4) and pelvic cavity (n = 2). Twenty three patients had bone marrow metastasis. Twelve patients had bone metastasis. All patients were treated with the CDV protocol (cyclophosphamide + doxorubicin + vincristine) for 3 cycles and the CiE protocol (cisplatin + etoposide) for 2 cycles. Neuroblastoma therapeutic response evaluation criterion and common terminology criteria for adverse events of National Cancer Institute were used to evaluate effects and chemotherapy related toxicity.</p><p><b>RESULTS</b>All patients received the pre-operative chemotherapy. The overall response rate was 82%. After chemotherapy, 24 patients received operations. Total resection of primary tumor was found in 14 patients (58%) and part resection in 10 patients (42%). The most common chemotherapy related toxicity was bone marrow suppression: grade IV suppression of neutrophils (n = 27), reduction in hemoglobin (III grade, n = 7; IV grade, n = 20) and reduction in platelet (III grade, n = 2; IV grade, n = 25). Infection was found in all patients and was controlled with antibiotics. I or II grade lesions of digestive, liver and kidney were found and could be recovered after therapy. Grade I neurotoxicity occurred in 2 patients (7%). The heart function damage was not found in any of patients.</p><p><b>CONCLUSIONS</b>The protocol of CDV combined with CiE as pre-operative chemotherapy might be effective in children with stage IV neuroblastoma.</p>
Full text:
1
Database:
WPRIM
Main subject:
Vincristine
/
Antineoplastic Combined Chemotherapy Protocols
/
Retrospective Studies
/
Cisplatin
/
Cyclophosphamide
/
Dacarbazine
/
Therapeutic Uses
/
Drug Therapy
/
Etoposide
/
Neuroblastoma
Type of study:
Etiology_studies
/
Guideline
/
Observational_studies
Limits:
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Language:
Zh
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2009
Document type:
Article