Roles of matrix metalloproteinases, tissue inhibitor of matrix metalloproteinase and hs-CRP in Kawasaki disease / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 989-991, 2009.
Article
in Zh
| WPRIM
| ID: wpr-305139
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To examine the expression of matrix metalloproteinases (MMP)-2, -9, tissue inhibitor of matrix metalloproteinase (TIMP)-1 and hs-CRP, and their relationship with coronary artery in children with Kawasaki disease.</p><p><b>METHODS</b>One hundred and fifty-one children with Kawasaki disease (111 cases with coronary artery damage and 40 cases without) and 60 healthy children were enrolled. The expression of MMP-2, MMP-9 and TIMP-1 was detected using ELISA, and the hs-CRP concentration was measured using the endpoint nephelometry.</p><p><b>RESULTS</b>There were significant differences in the level of MMP-2, MMP-9 and hs-CRP between the patients with or without coronary artery damage and the healthy children (p<0.05). The levels of MMP-2, MMP-9 and hs-CRP were the highest in the cardiovascular damage group (p<0.05). There were positive correlations between MMP-2, MMP-9 and TIMP-1 in children with Kawasaki disease.</p><p><b>CONCLUSIONS</b>MMP-2, MMP-9, TIMP-1 and hs-CRP may play important roles in the development of Kawasaki disease. The combined measurement of MMP-2, MMP-9 and hs-CRP may be useful in the evaluation of the severity in children with Kawasaki disease.</p>
Full text:
1
Database:
WPRIM
Main subject:
Blood
/
C-Reactive Protein
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Tissue Inhibitor of Metalloproteinase-1
/
Matrix Metalloproteinase 2
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Matrix Metalloproteinase 9
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Mucocutaneous Lymph Node Syndrome
Limits:
Child
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Child, preschool
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Female
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Humans
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Infant
/
Male
Language:
Zh
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2009
Document type:
Article