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Preparation of hydrophilic matrix sustained release tablets of total lactones from Andrographis paniculata and study on its in vitro release mechanism / 中国中药杂志
Article in Chinese | WPRIM (Western Pacific) | ID: wpr-305345
Responsible library: WPRO
ABSTRACT
In this study, hydrophilic matrix sustained release tablets of total lactones from Andrographis paniculata were prepared and the in vitro release behavior were also evaluated. The optimal prescription was achieved by studying the main factor of the type and amount of hydroxypropyl methylcellulose (HPMC) using single factor test and evaluating through cumulative release of three lactones. No burst drug release from the obtained matrix tablets was observed. Drug release sustained to 14 h. The release mechanism of three lactones from A. paniculata was accessed by zero-order, first-order, Higuchi and Peppas equation. The release behavior of total lactones from A. paniculata was better agreed with Higuchi model and the drug release from the tablets was controlled by degradation of the matrix. The preparation of hydrophilic matrix sustained release tablets of total lactones from A. paniculata with good performance of drug release was simple.
Subject(s)
Full text: Available Database: WPRIM (Western Pacific) Main subject: Tablets / Drugs, Chinese Herbal / Kinetics / Chemistry / Andrographis / Delayed-Action Preparations / Drug Compounding / Hydrophobic and Hydrophilic Interactions / Lactones / Methods Type of study: Prognostic study Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2015 Document type: Article
Full text: Available Database: WPRIM (Western Pacific) Main subject: Tablets / Drugs, Chinese Herbal / Kinetics / Chemistry / Andrographis / Delayed-Action Preparations / Drug Compounding / Hydrophobic and Hydrophilic Interactions / Lactones / Methods Type of study: Prognostic study Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2015 Document type: Article
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