Effect of preoperative use of long-acting octreotide on growth hormone secreting pituitary adenoma and transsphenoidal surgery / 中国医学科学杂志(英文版)
Chinese Medical Sciences Journal
; (4): 23-26, 2005.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-305468
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate whether somatostatin analog octreotide long acting release (LAR) shrinks growth hormone (GH) secreting adenomas, and improves the results of subsequent transsphenoidal surgery.</p><p><b>METHODS</b>Seventeen previously untreated active acromegalic patients with pituitary adenomas were treated with LAR (30 mg intramuscular injection every 28 days) for 3 months prior to transsphenoidal surgery. Clinical reaction, mean GH secretion, and tumor volume were measured under basal conditions and after LAR treatment.</p><p><b>RESULTS</b>Presurgical treatment improved acromegaly symptoms and induced a significant reduction of GH under the 5 ng/mL limit in microadenoma (P < 0.05), while only 18.2% (2/11) in macroadenoma. Meanwhile, tumor shrinkage occurred in 58.8% (10/17) patients, with 1 case in the microadenoma group. All marked shrinkage (> 25%) occurred in the macroadenoma group. Statistical analysis showed tumor shrinkage caused by LAR was greater in macroadenoma group than that in microadenoma group (P < 0.05). During operation, adenoma was soft in 15 cases, with the exception of 2 cases in which the soft tumor was divided by fibrous septa, but all tumor removal was smooth.</p><p><b>CONCLUSIONS</b>A short term administration of preoperative LAR may induce a significant decrease in GH-secretion level and adenoma volume. Presurgical use of octreotide LAR improves surgical results especially in macroadenomas.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pituitary Neoplasms
/
General Surgery
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Acromegaly
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Preoperative Care
/
Octreotide
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Adenoma
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Antineoplastic Agents, Hormonal
/
Human Growth Hormone
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Bodily Secretions
/
Delayed-Action Preparations
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
Chinese Medical Sciences Journal
Year:
2005
Document type:
Article