Testosterone-induced spermatogenic impairment is associated with looser arrangement of spermatogenic cells in rats / 中华男科学杂志
National Journal of Andrology
; (12): 507-510, 2011.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-305855
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To determine whether testosterone-induced intra-testicular testosterone withdrawal and therefore spermatogenic impairment is associated with looser arrangement of spermatogenic cells in rats.</p><p><b>METHODS</b>Adult male SD rats received intramuscular injection of testosterone undecanoate at 19 mg/(kg x 15 d) for 130 days, and then testicular tissue blocks were obtained for the preparation of methacrylate resin-embedded sections and observation of the changes in testicular histology.</p><p><b>RESULTS</b>Apart from such changes as impaired spermiogenesis and spermiation, apparently looser arrangement of spermatogenic cells was seen in 11.5% of the seminiferous tubule profiles, with radial cracks (empty spaces) running towards the tubule lumen being formed between lines, bundles or groups of spermatogenic cells (mainly spermatids and spermatocytes).</p><p><b>CONCLUSION</b>Looser arrangement of spermatogenic cells is one of the key histological changes resulting from intra-testicular testosterone withdrawal in rats.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Seminiferous Tubules
/
Spermatogenesis
/
Testis
/
Testosterone
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Rats, Sprague-Dawley
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Cell Biology
Limits:
Animals
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2011
Document type:
Article