Your browser doesn't support javascript.
loading
Analysis of clinical and pathological features of chronic hepatitis B with hepatic steatosis / 中华肝脏病杂志
Chinese Journal of Hepatology ; (12): 817-820, 2009.
Article in Chinese | WPRIM (Western Pacific) | ID: wpr-306637
Responsible library: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore clinical and pathological features of chronic hepatitis B (CHB) with hepatic steatosis.</p><p><b>METHODS</b>Retrospective analysis of hepatic steatosis in patients with liver biopsy-proven CHB between January 2005 and June 2008. Detailed clinical, laboratory and pathological data of CHB patients with steatosis were compared with those in sex-, age- matched CHB patients without steatosis. Patients co-infected hepatitis C virus or HIV or suffering from liver diseases of other causes were excluded.</p><p><b>RESULTS</b>Histological hepatic steatosis was found in 33.4% of the 1263 CHB patients. The prevalence of steatosis was increased with time in the study period (20.3%, 28.2%, 32.6%, 65.4%, in trend analysis, P values less than 0.05). Body mass index, fasting plasma glucose, serum triglyceride and total cholesterol level in CHB patients with hepatic steatosis (n = 114) were significantly higher than those in 113 patients without steatosis (t values were 6.811, 2.733, 3.063, 2.340, respectively, P values less than 0.01 or 0.05). Compared to patients without steatosis, serum hepatitis B virus DNA titer in patients with steatosis was significantly lower (x2 = 6.154, P less than 0.05) and reduced sharply with the increased degree of hepatic steatosis (x2 = 4.941, P less than 0.05). There were no differences in liver biochemical test (t values were 0.744, 1.390, -0.029, -1.175, 1.393, respectively, P values more than 0.05), hepatic inflammation grade and fibrosis stage between CHB patients with and without steatosis (x2 = 1.434, 0.106, respectively, P more than 0.05), and these parameters were not associated with different degree of hepatic steatosis (x2 = 2.447, 2.911, respectively, P more than 0.05).</p><p><b>CONCLUSIONS</b>Hepatic steatosis is common in patients with CHB, and is related to metabolic disorders. Hepatic steatosis does not affect the severity of CHB. The reverse association of hepatitis B virus titer with the degree of hepatic steatosis needs further investigation.</p>
Subject(s)
Full text: Available Health context: SDG3 - Health and Well-Being Health problem: Target 3.3: End transmission of communicable diseases Database: WPRIM (Western Pacific) Main subject: Pathology / Virology / Blood / Severity of Illness Index / DNA, Viral / Biomarkers / Body Mass Index / Hepatitis B virus / Cholesterol / Epidemiology Type of study: Etiology study / Observational study / Risk factors Limits: Female / Humans / Male Language: Chinese Journal: Chinese Journal of Hepatology Year: 2009 Document type: Article
Full text: Available Health context: SDG3 - Health and Well-Being Health problem: Target 3.3: End transmission of communicable diseases Database: WPRIM (Western Pacific) Main subject: Pathology / Virology / Blood / Severity of Illness Index / DNA, Viral / Biomarkers / Body Mass Index / Hepatitis B virus / Cholesterol / Epidemiology Type of study: Etiology study / Observational study / Risk factors Limits: Female / Humans / Male Language: Chinese Journal: Chinese Journal of Hepatology Year: 2009 Document type: Article
...