Study of copper metabolism and liver damage in TX Mice-an animal model for liver disease / 中华肝脏病杂志
Chinese Journal of Hepatology
; (12): 688-690, 2009.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-306701
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To provide right time points in selection of right aged animals and the normal physiological data of TX mice.</p><p><b>METHODS</b>7-12 months old TX and DL mice were studied, each group contained 3 female and 3 male mice of TX or DL mice. The concentration of copper in the serum, dry tissues (liver, brain and kidney), together with copper biochemistry indexes were measured. The liver histopathology was observed under light microscopy and electron microscope.</p><p><b>RESULTS</b>Transaminase increased significantly only in 10 and 11-month- old (AST(TX10) = 218.3 U/L, AST(TX11) = 197.5 U/L, AST(DL10) = 171.5 U/L, AST(DL11) = 165.0 U/L, P(10) less than 0.001, P(11) = 0.022), but the copper concentration of liver, brain and kidney was significantly increased during 7-12 month old (the average concentration of copper, Liver(TX) = (750.0 +/- 85.5) mg/kg, Brain(TX) = (39.7 +/- 2.2)mg/kg, Kidney(TX) = (29.8 +/- 5.0) mg/kg, Liver(DL) = (11.6 +/- 1.5) mg/kg, Brain(DL) = (16.8 +/- 0.9) mg/kg, Kidney(DL) = (14.2 +/- 1.0) mg/kg, t = 21.16, 23.60, 7.47, for all these organs P less than 0.05).</p><p><b>CONCLUSION</b>TX mice is a suitable model of liver disease with natural recovery, so selecting animal model of suitable time point is very important.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Aspartate Aminotransferases
/
Time Factors
/
Blood
/
Brain
/
Ceruloplasmin
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Copper
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Disease Models, Animal
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Kidney
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Liver
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Hepatology
Year:
2009
Document type:
Article