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Association of the polymorphism in manganese superoxide dismutase gene with diabetic retinopathy in Chinese type 2 diabetic patients / 中华医学遗传学杂志
Article in Chinese | WPRIM (Western Pacific) | ID: wpr-308041
Responsible library: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association of the polymorphism in manganese superoxide dismutase (Mn-SOD) gene in Chinese type 2 diabetic patients with diabetic retinopathy.</p><p><b>METHODS</b>The Ala(-9)Val polymorphism of the Mn-SOD gene was determined by polymerase chain reaction and direct sequencing in 198 normal control subjects and 264 patients with type 2 diabetes mellitus, among them there were 139 non-diabetic retinopathy (NDR) subjects and 125 subjects with diabetic retinopathy (DR).</p><p><b>RESULTS</b>There was no statistic difference in the frequencies of VV genotype and V allele between the type 2 diabetic group and the control group. However, the frequencies of VV genotype and V allele were significantly higher in the DR group than that in the NDR group (chi-square (2)=5.015, P=0.025; chi(2)=10.253, P=0.001),but there was no statistic difference in the NDR group compared with the control group (P > 0.05). The presence of V allele was shown to be associated with diabetic retinopathy (OR=1.96, 95%CI 1.29-2.97). Furthermore, the subjects carrying the VV genotype had lower serum Mn-SOD level (P=0.025) and had a tendency of higher total serum SOD activity, but this tendency had no statistic significance.</p><p><b>CONCLUSION</b>The Ala(-9)Val polymorphism in the Mn-SOD gene may not be related to the etiology of type 2 diabetes, but it seems to contribute to the development of diabetic retinopathy in Chinese type 2 diabetic patients.</p>
Subject(s)
Full text: Available Database: WPRIM (Western Pacific) Main subject: Polymorphism, Genetic / Superoxide Dismutase / DNA / Polymerase Chain Reaction / Polymorphism, Single Nucleotide / Asian People / Diabetes Mellitus, Type 2 / Diabetic Retinopathy / Alleles / Genetics Limits: Female / Humans / Male Language: Chinese Journal: Chinese Journal of Medical Genetics Year: 2008 Document type: Article
Full text: Available Database: WPRIM (Western Pacific) Main subject: Polymorphism, Genetic / Superoxide Dismutase / DNA / Polymerase Chain Reaction / Polymorphism, Single Nucleotide / Asian People / Diabetes Mellitus, Type 2 / Diabetic Retinopathy / Alleles / Genetics Limits: Female / Humans / Male Language: Chinese Journal: Chinese Journal of Medical Genetics Year: 2008 Document type: Article
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