The advances in research on phosphorylation of polyglutamine disease / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 414-417, 2008.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-308051
Responsible library:
WPRO
ABSTRACT
Polyglutamine (polyQ) diseases are a group of hereditary neurodegenerative disorders caused by expansion of a glutamine repeat in responsible gene products. To date, the pathogenesis of polyQ diseases is still not very clear, but many researches suggest that phosphorylation of mutant proteins plays a critical role on the process of Huntington's disease, dentatorubral-pallidoluysian atrophy, spinal bulbar muscular atrophy, spinocerebellar ataxia1 and spinocerebellar ataxia 3/Machado-Joseph disease.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Peptides
/
Phosphorylation
/
Physiology
/
Muscular Atrophy, Spinal
/
Spinocerebellar Degenerations
/
Huntington Disease
/
Machado-Joseph Disease
/
Trinucleotide Repeats
/
Trinucleotide Repeat Expansion
/
Heredodegenerative Disorders, Nervous System
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2008
Document type:
Article