Massive Fetomaternal Hemorrhage Diagnosed with High-performance Liquid Chromatography / 임상소아혈액종양
Clinical Pediatric Hematology-Oncology
; : 158-161, 2016.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-30885
Responsible library:
WPRO
ABSTRACT
Massive fetomaternal hemorrhage (FMH) is a major cause of unexplained fetal death and neonatal anemia. FMH can be diagnosed using the Kleihauer-Betke test or flow cytometry by identifying the presence of fetal red cells in the maternal blood. However, timely diagnosis is a challenge because many hospitals lack the equipment needed to perform such tests. The authors experienced a case of FMH diagnosed via high-performance liquid chromatography (HPLC) which is generally used in measuring glycated hemoglobin (HbA1c) in a patient with unexplained neonatal anemia. A girl aged 2 days was transferred to our hospital for showing pallor and a hemoglobin level of 5.0 g/dL. HPLC revealed 3% fetal hemoglobin (HbF) in the maternal blood. HPLC is a quick test for quantifying HbF that is readily available in many hospitals and could serve as a promising alternative for diagnosing FMH.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pallor
/
Prothrombin Time
/
Fetal Hemoglobin
/
Glycated Hemoglobin
/
Chromatography, High Pressure Liquid
/
Chromatography, Liquid
/
Diagnosis
/
Fetal Death
/
Fetomaternal Transfusion
/
Flow Cytometry
Type of study:
Diagnostic study
Limits:
Female
/
Humans
/
Infant, Newborn
/
Pregnancy
Language:
English
Journal:
Clinical Pediatric Hematology-Oncology
Year:
2016
Document type:
Article