Lung adenoma development and NK activity in mice treated with multiple carcinogens
Journal of Korean Medical Science
; : 1-5, 1992.
Article
in En
| WPRIM
| ID: wpr-30961
Responsible library:
WPRO
ABSTRACT
A wide-spectrum initiation model was investigated in mice. Sequential treatments with diethylnitrosamine, urethane and N-methylnitrosourea, with or without a promoter, phenobarbital, resulted in tumor formation in the lungs in 85-90% of animals, but did not produce any tumorous lesions in other organs. The lung tumors were adenomas and the mean number of adenomas was 2.2-2.6 per mouse. Phenobarbital combination had no additive effect on lung tumor incidence and multiplicity. Splenic NK cell activity showed inconsistent increment in the carcinogen plus phenobarbital-treated group during the experiment (P less than 0.05).
Key words
Full text:
1
Database:
WPRIM
Main subject:
Phenobarbital
/
Urethane
/
Killer Cells, Natural
/
Random Allocation
/
Adenoma
/
Diethylnitrosamine
/
Lung Neoplasms
/
Methylnitrosourea
Limits:
Animals
Language:
En
Journal:
Journal of Korean Medical Science
Year:
1992
Document type:
Article