Relationship between ERCC2 single nucleotide polymorphisms and male idiopathic infertility in Ningxia / 中华男科学杂志
National Journal of Andrology
; (12): 419-422, 2014.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-309696
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the influence of the DNA repair gene ERCC2 single nucleotide polymorphisms (SNPs) rs13181, rs1618536, and rs1799793 on male idiopathic infertility in Ningxia, China.</p><p><b>METHODS</b>Using MassArray, we conducted a case-control study and genotyped three ERCC2 SNPs rs13181, rs1618536, and rs1799793 for 351 males (aged 31.0 +/- 4.2 years) with idiopathic infertility and another 327 normal fertile men (aged 33.0 +/- 5.9 years) as controls.</p><p><b>RESULTS</b>The ERCC2 AnyG-anyA-anyA genotypes were significantly associated with an increased risk of idiopathic infertility (OR 0.414, 95% CI 0.176 - 0.970), while the three single ERCC2 SNPs rs13181, rs1618536, and rs1799793 showed no significant differences between the cases and controls (P > 0.05).</p><p><b>CONCLUSION</b>The ERCC2 SNPs rs13181, rs1618536, and rs1799793 play a role of interaction in male idiopathic infertility in Ningxia, contributing to the risk of the disease.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Case-Control Studies
/
China
/
Polymorphism, Single Nucleotide
/
DNA Repair
/
Xeroderma Pigmentosum Group D Protein
/
Genetics
/
Genotype
/
Infertility, Male
Type of study:
Observational study
/
Risk factors
Limits:
Adult
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2014
Document type:
Article