Reduced expression of alpha-tocopherol-associated protein is associated with tumor cell proliferation and the increased risk of prostate cancer recurrence / 亚洲男科学杂志(英文版)
Asian Journal of Andrology
; (6): 206-212, 2007.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-310520
Responsible library:
WPRO
ABSTRACT
<p><b>AIM</b>To examine the impact and prognostic significance of alpha-tocopherol associated protein (TAP) expression in a series of prostate cancer patients.</p><p><b>METHODS</b>Tissues from 87 patients underwent radical prostatectomy were examined for TAP expression by immunohistochemistry. The relationships of the staining results, the clinic pathological characteristics and the recurrence times were analyzed.</p><p><b>RESULTS</b>Compared with the adjacent areas of normal and benign glands, immunoreactivity of TAP was reduced in areas of prostate cancer. A lower TAP-positive cell number per mm(2) of the largest cancer area (defined as TAP-PN) was associated with higher clinical stage (r = -0.248, P = 0.0322). Inverse associations were found among the TAP-PN and positive lymph nodes (r = -0.231, P = 0.0325), preoperative prostate-specific antigen (PSA) levels (r = -0.423, P = 0.0043), tumor size (r= -0.315, P= 0.0210) and elevated tumor cell proliferation, which was indicated by the staining of Ki-67 (r = -0.308, P = 0.0026). TAP-PN was a significant predictor of recurrence univariately (P = 0.0006), as well as multivariately, adjusted for known markers including preoperative PSA, clinical stage, Gleason score, surgical margin, extra-prostatic extension, seminal vesicle invasion and lymph node metastasis (P = 0.0012).</p><p><b>CONCLUSION</b>Reduced expression of TAP was associated with the cell proliferation status of prostate cancer, adverse pathological parameters and the increased risk of recurrence.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Prostatic Neoplasms
/
Carrier Proteins
/
Gene Expression Regulation, Neoplastic
/
Trans-Activators
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Ki-67 Antigen
/
Cell Proliferation
/
Genetics
/
Lipoproteins
/
Metabolism
Type of study:
Etiology study
/
Prognostic study
Limits:
Aged
/
Humans
/
Male
Language:
English
Journal:
Asian Journal of Andrology
Year:
2007
Document type:
Article