Arrhythmia triggered by stretching rabbit left ventricles and the block effect of streptomysin / 中国应用生理学杂志
Chinese Journal of Applied Physiology
; (6): 286-289, 2008.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-310744
Responsible library:
WPRO
ABSTRACT
<p><b>AIM</b>To observe the effect of stretching left ventricles in the end of action potential on rabbit cardiac activity, and to investigate its possible mechanisms.</p><p><b>METHODS</b>Stretch (120 mmHg, 50 ms) was applied in the end of action potential by the pressure-clamp technique to observe if there would be any changes in rabbit cardiac activity and streptomycin (500 micromol/L) was used to identify the mechanism.</p><p><b>RESULTS</b>Stretch in the end of action potential caused arrhythmia (P < 0.05) and streptomycin blocked the above effect (P < 0.05).</p><p><b>CONCLUSION</b>Streptomycin could block the effect of stretching left ventricles in the end of action potential on rabbit cardiac activity, which indicates that stretch-activated ion channels involve it.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Physiology
/
Arrhythmias, Cardiac
/
Proprioception
/
In Vitro Techniques
/
Action Potentials
/
Streptomycin
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Heart Ventricles
/
Ion Channels
/
Mechanoreceptors
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Applied Physiology
Year:
2008
Document type:
Article