Delayed protection of HO-1 in the exercise preconditioning from the myocardial relative ischemic reperfusion injury / 中国应用生理学杂志

ABSTRACT

<p><b>AIM</b>To explore the role of HO-1 in the exercise preconditioning protecting the rat myocardium from the relative myocardial ischemia/reperfusion injury (rI/R).</p><p><b>METHODS</b>40 Wistar rats were divided into 5 groups randomly control group (CN), relative ischemia/reperfusion group (IR), exercise preconditioning + relative ischemia-reperfusion group (EI), HO-1 revulsant group (HE) and exercise preconditioning + HO-1 inhibitor (EZ) group. We detected the cardiac function parameter--pressure-rate product (PRP), the levels of MDA in coronary effluent and the activity of HO-1.</p><p><b>RESULTS</b>The activities of HO-1 of EI group and HE group were higher significantly than the IR group. EZ group was lower than EI group. There was significant difference between EI group and HE group. The recovery rate of PRP in the 60 min point of reperfusion of EI group was higher significantly than IR group. EZ group was lower than EI group. There was significant difference between HE group and IR group in 30 min point of reperfusion. The levels of MDA in coronary effluent after rI/R of EI group, EZ group and HE group were lower significantly than IR group. There was significant difference between EI group and EZ group.</p><p><b>CONCLUSION</b>EP can activate the HO-1 which can ameliorate the rI/R injury occurred after 24 hours.</p>