Role of Diabetes Mellitus on Treatment Effects in Drug-susceptible Initial Pulmonary Tuberculosis Patients in China / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
; (12): 671-675, 2017.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-311363
Responsible library:
WPRO
ABSTRACT
We assessed the role of diabetes mellitus (DM) on treatment effects in drug-susceptible initial pulmonary tuberculosis (PTB) patients. A prospective study was conducted in eight provinces of China from October 2008 to December 2010. We enrolled 1,313 confirmed drug-susceptible initial PTB patients, and all subjects received the treatment regimen (2H3R3E3Z3/4H3R3) as recommended by the national guidelines. Of the 1,313 PTB patients, 157 (11.9%) had DM; these patients had more sputum smear-positive rates at the end of the second month [adjusted odds ratios (aOR) 2.829, 95% confidence intervals (CI) 1.783-4.490], and higher treatment failure (aOR 2.120, 95% CI 1.565-3.477) and death rates (aOR 1.536, 95% CI 1.011-2.628). DM was a contributing factor for culture-positive rates at the end of the second month and treatment failure and death of PTB patients, thus playing an unfavorable role in treatment effects of PTB.
Full text:
Available
Health context:
SDG3 - Health and Well-Being
/
Neglected Diseases
/
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Target 3.3: End transmission of communicable diseases
/
Neglected Diseases
/
Tuberculosis
/
Diabetes Mellitus
/
Endocrine System Diseases
/
Other Respiratory Diseases
Database:
WPRIM (Western Pacific)
Main subject:
Therapeutics
/
Tuberculosis, Pulmonary
/
China
/
Epidemiology
/
Therapeutic Uses
/
Diabetes Mellitus
/
Drug Therapy
/
Microbiology
/
Mycobacterium tuberculosis
/
Antitubercular Agents
Type of study:
Practice guideline
/
Observational study
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Biomedical and Environmental Sciences
Year:
2017
Document type:
Article