Investigation of therapeutic mechanism of Weiweifang on experimental gastric ulcer in rats viewing from metabonomics / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
; (12): 1073-1077, 2010.
Article
in Zh
| WPRIM
| ID: wpr-313160
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the therapeutic mechanism of Weiweifang (WWF, a Chinese herbal preparation) on gastric ulcer in rats viewing from metabonomics.</p><p><b>METHODS</b>Wistar rats were made to gastric model by acetic acid cauterization and randomized into the model group, the spontaneously healing group and the three WWF treatment groups, and a group of normal rats was set for control. Metabolic spectra of gastric mucosa extraction of rats were acquired with gas chromatography-mass spectrometry (GC-MS) technique. After being pre-processing, data were subjected to partial least squares discriminant analysis (PLS-DA) to discover the biomarkers in rats of the normal group and the model group. The therapeutic effect of WWF on experimental gastric ulcer was assessed by principal component analyses (PCA), and its action of mechanism was explained viewing from the changes of biomarkers.</p><p><b>RESULTS</b>Spectra of biomarkers, including organic acids, fatty acids, amino acids, etc. in model rats were statistically different to those in normal rats, which demonstrated that the energy and substance metabolisms were disordered in rats with gastric ulcer. WWF could cure gastric ulcer effectively by way of regulating the metabolism of gastric mucosa.</p><p><b>CONCLUSION</b>The therapeutic mechanism of WWF on experimental gastric ulcer in rats is revealed integrally by metabonomics in this study, displaying prominently the characteristics of Chinese medicine multiple targets comprehensive therapy.</p>
Full text:
1
Database:
WPRIM
Main subject:
Stomach Ulcer
/
Drugs, Chinese Herbal
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Rats, Wistar
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Acetic Acid
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Therapeutic Uses
/
Drug Therapy
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Fatty Acids
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Metabolomics
/
Gastric Mucosa
/
Amino Acids
Type of study:
Prognostic_studies
Limits:
Animals
Language:
Zh
Journal:
Chinese Journal of Integrated Traditional and Western Medicine
Year:
2010
Document type:
Article