Frequency of CYP2A6 gene deletion and its relation to risk of lung cancer / 中国肺癌杂志

ABSTRACT

<p><b>BACKGROUND</b>Cytochrome P450 2A6 (CYP2A6) plays an important role in oxidation of nicotine and in activation of tobacco-related carcinogens. It has been suggested that individuals with defective CYP2A6 allele are at a lower risk of developing lung cancer. This study is to investigate the frequency of CYP2A6 gene deletion and the relationship of CYP2A6 genetic polymorphism with lung cancer risk in Chinese.</p><p><b>METHODS</b>A case-control study which detected CYP2A6 genotype of 180 patients with lung cancer and 224 controls by PCR-based genotype assay was conducted.</p><p><b>RESULTS</b>No relationship was found between the frequency of CYP2A6 gene deletion and lung cancer risk. There was only one case of CYP2A6 del/del genotype in the controls. The frequency of CYP2A6 del allele was 13.8% in the controls, and 12.8% in lung cancer cases. The CYP2A6 del/del genotype was not found in lung cancer cases.</p><p><b>CONCLUSIONS</b>There is no difference in frequency of CYP2A6 gene deletion between lung cancer cases and controls.</p>