Association of cooking oil fumes exposure and oxidative DNA damage among occupational exposed populations / 中华劳动卫生职业病杂志
Chinese Journal of Industrial Hygiene and Occupational Diseases
; (12): 574-578, 2010.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-313526
Responsible library:
WPRO
ABSTRACT
<p><b>BACKGROUND</b>Previous investigations indicate that cooks are exposed to polycyclic aromatic hydrocarbons (PAH) from cooking oil fumes (COF). However, Emission of PAH and their carcinogenic potencies from cooking oil fumes sources have not been investigated among cooks.</p><p><b>AIMS</b>To investigate the urinary excretion of a marker for oxidative DNA damage, 8-hydroxydeoxyguanosine (8-OHdG), in different groups of cooks and different exposure groups, and to study the association between 8-OHdG and 1-hydroxypyrene (1-OHP), a biological marker for PAH exposure.</p><p><b>METHODS</b>Urine samples were collected from different groups of cooks (n = 86) and from unexposed controls (n = 36), all are male with similar age and smoking habits. The health status, occupational history, smoking, and alcohol consumption 24 hours prior to sampling was estimated from questionnaires. The urinary samples were frozen for later analyses of 8-OHdG and 1-OHP by high performance liquid chromatography.</p><p><b>RESULTS</b>Excretion in urine of 8-OHdG were similar for controls (mean 1.2 µmol/mol creatinine, n = 36), and for those who had been in the kitchen room with exhaust hood operation (mean 1.5 µmol/mol creatinine, n = 45). COF exposed cooks without exhaust hood operation had increased excretion of 8-OHdG (mean 2.3 µmol/mol creatinine, n = 18). The difference between this group and the unexposed controls was significant. The urinary levels of ln 1-OHP and ln 8-OHdG were still significantly correlated in a multiple regression analysis.</p><p><b>CONCLUSION</b>Results indicate that exposure to PAH or possibly other compounds in COF may cause oxidative DNA damage.</p>
Full text:
Available
Health context:
SDG3 - Target 3.9 Reduce the amount of deaths produced by dangerous chemicals and the pollution of the air, water and soil
/
SDG3 - Health and Well-Being
Health problem:
Occupational Exposures
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Target 3.9: Reduce the amount of deaths produced by dangerous chemicals and the pollution of the air, water and soil
Database:
WPRIM (Western Pacific)
Main subject:
Polycyclic Aromatic Hydrocarbons
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Urine
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DNA Damage
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Oils
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Surveys and Questionnaires
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Occupational Exposure
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Oxidative Stress
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Cooking
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Deoxyguanosine
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Air Pollutants, Occupational
Aspects:
Patient-preference
Limits:
Adult
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Humans
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Male
Language:
Chinese
Journal:
Chinese Journal of Industrial Hygiene and Occupational Diseases
Year:
2010
Document type:
Article