Translocation of p53 Protein in Melanocytes and Malignant Melanoma Cells After UVB Irradiation
Annals of Dermatology
; : 133-138, 2001.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-31374
Responsible library:
WPRO
ABSTRACT
BACKGROUND:
UVB is responsible for most of the carcinogenic effects of sun exposure.OBJECTIVE:
Aim of this study was to investigate the regulation and intracellular redistribution of p53 protein after UVB irradiation.METHODS:
Cultured normal human melanocytes and G361 melanoma cells were used for west-ern blotting and confocal microscopic examination for determining expression and distribution of p53.RESULTS:
UVB irradiation increased p53 expression in cultured normal human melanocytes and G361 malignant melanoma cells according to increasing doses of UVB. Furthermore, p53 moved from cytosol to nucleus after UVB irradiation.CONCLUSIONS:
UVB irradiation induced overexpression and redistribution of p53 in cultured normal human melanocytes and G361 malignant melanoma cells.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Solar System
/
Cytosol
/
Melanocytes
/
Melanoma
Limits:
Humans
Language:
English
Journal:
Annals of Dermatology
Year:
2001
Document type:
Article